Social inequalities lie at the heart of risk of HIV infection among wo
men in the United States. As of December, 1995, 71,818 US women had de
veloped AIDS-defining diagnoses. These women have been disproportionat
ely poor, African-American, and Latina. Their neighborhoods have been
burdened by poverty, racism, crack cocaine, heroin, and violence. To e
xplain which women are at risk and why, this article reviews the epide
miology of HIV and AIDS among women in light of four conceptual framew
orks linking health and social justice: feminism, social production of
disease/political economy of health, ecosocial, and human rights. The
article applies these alternative theories to describe sociopolitical
contexts for AIDS' emergence and spread in the United States, and rev
iews evidence linking inequalities of class, race/ethnicity, gender, a
nd sexuality, as well as strategies of resistance to these inequalitie
s, to the distribution of HIV among women.