Sj. Gregson et al., Synthesis of a novel C2/C2 '-exo unsaturated pyrrolobenzodiazepine cross-linking agent with remarkable DNA binding affinity and cytotoxicity, CHEM COMMUN, (9), 1999, pp. 797-798
A C2/C2'-exo unsaturated pyrrolobenzodiazepine dimer 1 has been synthesised
which is cytotoxic at the picomolar level and has remarkable covalent DNA
binding affinity, raising the melting temperature of duplex-form calf thymu
s DNA by 34 degrees C after 18 h incubation.