Synthesis and screening for anti-HIV activity of some N-Mannich bases of isatin derivatives

Authors
Pandeya, SN Yogeeswari, P Sriram, D de Clercq, E Pannecouque, C Witvrouw, M
Citation
Sn. Pandeya et al., Synthesis and screening for anti-HIV activity of some N-Mannich bases of isatin derivatives, CHEMOTHERA, 45(3), 1999, pp. 192-196
Citations number
9
Categorie Soggetti
Pharmacology,"Pharmacology & Toxicology
Journal title
CHEMOTHERAPY
ISSN journal
00093157 → ACNP
Volume
45
Issue
3
Year of publication
1999
Pages
192 - 196
Database
ISI
SICI code
0009-3157(199905/06)45:3<192:SASFAA>2.0.ZU;2-V
Abstract
The effect of about 12 new compounds of Mannich bases of isatin against HIV -1 (IIIB) and HIV-2 (ROD) strains in MT 4 cells was studied. The screening method employed was MTT, In initial studies, one compound has shown maximum protection of 16% in subtoxic concentration.