Mgf. Sharp et al., GENOTYPE AND CARDIOVASCULAR PHENOTYPE - LESSONS FROM GENETICALLY MANIPULATED ANIMALS AND DISEASED HUMANS, Current opinion in nephrology and hypertension, 6(1), 1997, pp. 51-57
Recent advances in our understanding of the molecular genetic basis of
cardiovascular diseases have been facilitated through animal models a
nd human case studies. The identification of genes that contribute to
human disease leads to functional studies of disease-associated mutati
ons, and the use of genetically manipulated animals in these types of
study are providing important insights into molecular mechanisms in vi
vo. This article reviews some genetically manipulated animal models of
cardiovascular diseases, and their relevance to human conditions. App
lication of these approaches to address physiological questions is als
o discussed.