Management of Darier's disease

Darier's disease is an uncommon inherited cutaneous disease which is diffic ult to manage, especially in adolescence. The warty keratotic papules irrit ate, smell and look unsightly. Histologically, the condition is characteriz ed by the presence of focal acantholytic dyskeratosis, Treatment is unsatis factory, particularly in patients with erosive flexural disease, but retino ids reduce the hyperkeratosis. Now the mutation causing Darier's disease ha s been identified, there is a real possibility of more effective treatment in the future.