Glucotoxicity - Potential mechanisms

Authors
Mooradian, AD Thurman, JE
Citation
Ad. Mooradian et Je. Thurman, Glucotoxicity - Potential mechanisms, CLIN GERIAT, 15(2), 1999, pp. 255
Citations number
59
Categorie Soggetti
General & Internal Medicine
Journal title
CLINICS IN GERIATRIC MEDICINE
ISSN journal
07490690 → ACNP
Volume
15
Issue
2
Year of publication
1999
Database
ISI
SICI code
0749-0690(199905)15:2<255:G-PM>2.0.ZU;2-O
Abstract
Plasma concentration of glucose is found within a relatively narrow range o f values for most animal species, yet it has little correlation with maximu m lifespan; however, hyperglycemia in most animals is associated with prema ture death. This article presents evidence for hyperglycemia-induced tissue toxicity and discusses potential mechanisms of glucotoxicity and implicati ons for the aging organism.