ANTINOCICEPTION INDUCED BY SM-32 DEPENDS ON A CENTRAL CHOLINERGIC MECHANISM

Citation
C. Ghelardini et al., ANTINOCICEPTION INDUCED BY SM-32 DEPENDS ON A CENTRAL CHOLINERGIC MECHANISM, Pharmacological research, 35(2), 1997, pp. 141-147
Citations number
22
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
ISSN journal
10436618
Volume
35
Issue
2
Year of publication
1997
Pages
141 - 147
Database
ISI
SICI code
1043-6618(1997)35:2<141:AIBSDO>2.0.ZU;2-H
Abstract
The antinociceptive effect of SM 32 was examined in mice by using the hot-plate (10-40 mg kg(-1) i.p; 3-30 mu g per mouse i.c.v.) and abdomi nal constriction (10-30 mg kg(-1) i.p) tests. In the antinociceptive d ose-range, SM 32 did not impair mouse spontaneous motility and motor c oordination evaluated respectively by the Animex and rota-rod tests. T he increase in the pain threshold produced by SM 32 was prevented by d icyclomine, pirenzepine and hemicholinium-3 but not by naloxone and CG P 35348. In vitro experiments showed that the SM 32 amplified electric ally- and nicotine-evoked guinea-pig ileum contractions, On the basis of the above data, it can be postulated that SM 32 exerts its antinoci ceptive effect through a potentiation of central cholinergic transmiss ion. (C) 1997 The Italian Pharmacological Society.