Obesity: effects on the liver and gastrointestinal system

Obesity, or the presence of a body mass index exceeding 30 kg/m(2), has ass umed epidemic proportions in the United States. More than a cosmetic issue, obesity is associated with many comorbidities that contribute to multiple organ dysfunction, illness, and shortened lifespan. This review covers new and emerging information on the relationship of obesity to common and debil itating hepatic and gastrointestinal disorders, including nonalcoholic stea tohepatitis, gastroesophageal reflux, gallstones, and increased risk of col on cancer. Understanding the role of obesity in these disorders should lead to new insights into the pathogenesis of common liver and gastrointestinal diseases and to new treatment strategies for the practicing gastroenterolo gist.