II is possible to distinguish the various forms of pemphigus from one anoth
er using clinical, histologic, and immunologic criteria. Paraneoplastic pem
phigus, a recently defined type that is severe and often, fatal is associat
ed with an underlying malignancy. We present the second reported case of pe
mphigus associated with renal cell carcinoma. We do not believe that either
case represents paraneoplastic pemphigus, which suggests the possibility o
f some other link between these two diseases.