HOX11L1, a gene involved in peripheral nervous system development, maps tohuman chromosome 2p13.1 -> p12 and mouse chromosome 6C3-D1

Authors
Puliti, A Cinti, R Betsos, N Romeo, G Ceccherini, I
Citation
A. Puliti et al., HOX11L1, a gene involved in peripheral nervous system development, maps tohuman chromosome 2p13.1 -> p12 and mouse chromosome 6C3-D1, CYTOG C GEN, 84(1-2), 1999, pp. 115-117
Citations number
12
Categorie Soggetti
Molecular Biology & Genetics
Journal title
CYTOGENETICS AND CELL GENETICS
ISSN journal
03010171 → ACNP
Volume
84
Issue
1-2
Year of publication
1999
Pages
115 - 117
Database
ISI
SICI code
0301-0171(1999)84:1-2<115:HAGIIP>2.0.ZU;2-F
Abstract
HOX11L1 is a homeobox gene involved in peripheral nervous system developmen t as confirmed by knockout mice exhibiting megacolon with enteric ganglia, a phenotype associated in human with Intestinal Neuronal Dysplasia (IND). U sing FISH and radiation hybrids we have localized HOX11L1 to human chromoso me 2p13.1 --> p12, in a 14-cR interval between WI-5987 (D2S2088) and GCT1B4 (D2S2497), and confirmed the synteny between mouse 6C3D1 and human 2p13.1 --> p12 chromosomes by mapping an EST cDNA clone corresponding to mouse HOX 11L1 (Tlx2).