Synteny mapping of five human chromosome 7 genes on bovine chromosomes 4 and 21

Five genes on human chromosome 7 (HSA 7) were assigned to bovine chromosome 21 (BTA 21)and 4 (BTA 4) using a bovine-rodent somatic hybrid cell panel. These five genes were alpha-I subunit of adenylate cyclase-inhibiting G-pro tein (GNAI1), alpha/beta preprotachykinin (TAC1), reelin (RELN), c-AMP depe ndant protein kinase type II beta regulatory chain (PRKAR2B) and apolipopro tein A1 regulatory protein 1 (TFCOUP2). Four genes mapped to BTA 4 (GNAI1, TAC1, RELN, PRKAR2B) while one gene mapped to BTA 21 (TFCOUP2). This study confirms the synteny conservation between HSA 7 and BTA 4, finely maps the breakpoints of conserved synteny on HSA 7 and defines a new synteny conserv ation between HSA 7 and BTA 21.