Long-term efficacy of Humalog (R) in subjects with Type 1 diabetes mellitus

Aims To evaluate the long-term effectiveness of Humalog((R)) insulin in low ering post meal glucose excursions. Methods Twenty young subjects with Type 1 diabetes mellitus (DM) who had re ceived insulin-lispro (Humalog((R))) for a least 1 year (mean +/- SD 1.8 +/ - 1.6 years) were studied on two occasions, 3-14days apart. They consumed a similar breakfast consisting of 450-600 kCal having fasted overnight. The same amount of human soluble Humulin((R)) Regular or Humalog((R)) insulin w as given 10 min before the meal in a randomized, double-blind fashion. Results Postprandial glucose excursions at 30, 60, and 120 min were signifi cantly lower (P<0.001, ANCOVA) when subjects received Humalog((R)) as compa red to human soluble insulin. Serum-free insulin levels were significantly higher (P<0.001, ANOVA) at 30 and 60 min when subjects received Humalog((R) ) as compared with human soluble insulin. Humalog((R)) antibody levels afte r up to 5.4 years of receiving Humalog((R)) insulin were not elevated beyon d the values at 1 year. Conclusions We conclude that Humalog((R)) insulin is effective in lowering postprandial glucose excursions even after up to 5.4 years of treatment.