Be. Rittenhouse et al., At what price significance? The effect of price estimates on statistical inference in economic evaluation, HEALTH ECON, 8(3), 1999, pp. 213-219
Because data on resource utilization are now collected in many comparative
trials of health interventions, statistical analysis of between-group diffe
rences in mean costs has become common. Statistical analyses of costs are g
enerally performed conditional on a set of resource prices (or unit costs),
thereby suppressing any uncertainty associated with those price estimates.
Results presented here demonstrate that varying price estimates can have a
non-negligible effect on statistical inference regarding between-group cos
t differences. Depending on the relative prices used in an analysis, betwee
n-group differences in total costs per patient may be either statistically
significant or insignificant, regardless of whether differences in utilizat
ion of the underlying resources are statistically significant. These result
s highlight the importance of recognizing that evaluations based on patient
-level economic data may be sensitive to assumptions regarding the values o
f unobserved variables, such as the relative prices of resources. Tradition
al methods of sensitivity analysis remain a valuable tool for analysing the
implications of uncertainty around estimates of those unobserved variables
. Copyright (C) 1999 John Wiley & Sons, Ltd.