Acquired factor VIII inhibitor in a non-hemophilic patient with chronic hepatitis C viral infection

Production of coagulation factor VIII inhibitor is rarely encountered in no n-hemophilic patients. A 63-year-old Japanese male suffered from severe ble eding tendency caused by this inhibitor. Although he did not have malignanc y or collagen disease, he had chronic hepatitis C virus (HCV) infection, Al though HCV is known to induce production of various autoimmune antibodies, this may be the first report of a case with both acquired factor VIII inhib itor and HCV infection.