A generalized seizure following initiation of nelfinavir in a patient withhuman immunodeficiency virus type 1 infection, suspected due to interaction between nelfinavir and phenytoin

Authors
Honda, M Yasuoka, A Aoki, M Oka, S
Citation
M. Honda et al., A generalized seizure following initiation of nelfinavir in a patient withhuman immunodeficiency virus type 1 infection, suspected due to interaction between nelfinavir and phenytoin, INTERN MED, 38(3), 1999, pp. 302-303
Citations number
10
Categorie Soggetti
General & Internal Medicine
Journal title
INTERNAL MEDICINE
ISSN journal
09182918 → ACNP
Volume
38
Issue
3
Year of publication
1999
Pages
302 - 303
Database
ISI
SICI code
0918-2918(199903)38:3<302:AGSFIO>2.0.ZU;2-1
Abstract
Nelfinavir, one of human immunodeficiency virus (HIV) specific protease inh ibitors(PIs), is widely used for the treatment of HIV infection. Nelfinavir , which is metabolized with the cytochrome p450 isoforms, elevate the pheny toin level theoretically because nelfinavir acts as an inhibitor of phenyto in metabolism through the enzyme. However, we encountered a case of seizure recurrence caused by a lowered phenytoin level after initiation of nelfina vir, We should be aware of the change in the phenytoin level in concomitant use of nelfinavir.