Development and characterisation of supramolecular autovectoring system for selective drug delivery

Supramolecules since ages have been characterised as self-associating syste ms emanating the properties directly related to the mode of molecular assoc iation. Similar to supramolecules. liquid crystals may also be considered a s an associated system. The liquid crystals are defined as the stale of mat ter with the characterstic order of the crystal and the mobility of liquid. The system has been compared to the transporting form of cholesterol in bo dy. The present study reports autovectoring potentials of the drug liquid c rystals using diclofenac diethylammonium (DD) as a model. The drug based liquid crystals of DD were prepared employing temperature in duced transformation of isotropic form to the liquid crystal form. The prep ared liquid crystal systems were incubated with 1% phosphatidylcholine in o rder to stabilise the surface and restrict it into the liquid crystalline s tate. The system was characterised for viscosity variation, X-ray diffracti on pattern, partitioning behaviour and in vitro diffusion profile. Ii? vivo vectorising potential of the developed system was evaluated using rats as test animal and studying for the organ level distribution and drug compartm entalisation The system exhibited satisfactory vecterisation as significant amount of ad ministered dose was localised selectively in liver.