Sg. Teoh et al., Synthesis, crystal structure and biological activity of thiophene-2-carboxaldehyde thiosemicarbazone and its tin complexes, J ORGMET CH, 580(1), 1999, pp. 17-21
Thiophene-2-carboxaldehyde thiosemicarbazone, C4H3S-CH=N-NH-C(S)NH2 (tctscH
) obtained by the condensation reaction of thiophene-2-carboxaldehyde with
thiosemicarbazide forms SnPh2Cl(tctsc), 1 and SnCl2(tctsc)(2), 2 with SnPh2
Cl2 and SnPhCl3 in 1:1 and 1:2 tin:ligand molar ratios, respectively. The c
rystal structure determination shows that in both 1 and 2, tctscH is deprot
onated and functions as an anionic bidentate ligand, co-ordinating to the t
in atom through its azomethine-Ar and thiol-S atoms. The geometry about the
tin atom for complex 1 is distorted trigonal bipyramidal whereas for compl
ex 2 is distorted octahedral. Note that dephenylation occurs during the for
mation of complex 2. Fungitoxicity and cytotoxicity of the two tin complexe
s and tctscH have been evaluated and the biological activity is more remark
able in complex 1 in comparison to the other. (C) 1999 Elsevier Science S.A
. All rights reserved.