The non-aqueous titrimetric assay of the selected anti-inflammatory agentsusing tetra-n-butylammonium hydroxide as titrant

A potentiometric titration method in non-aqueous media is proposed for the determination of some commonly used anti-inflammatory agents. The direct po tentiometric titration of three anti-inflammatory agents, namely mefenamic acid, fenbufen and ibuprofen; and the indirect potentiometric titration of diclofenac sodium was carried out in acetonitrile solvent using tetra-n-but ylammonium hydroxide as titrant, at 25 degrees C and under a nitrogen atmos phere. The method was found to be highly accurate and precise, having a rel ative standard deviation of < 1.0% for all anti-inflammatory agents studied . Also, it was shown that the method could be successfully applied to the a ssay of commercial pharmaceuticals containing the above-mentioned anti-infl ammatory agents. The validity of the method was tested by the recovery stud ies of standard addition to pharmaceuticals and the results were found to b e satisfactory. The proposed method is simple, rapid and sufficiently preci se for quality control purposes. (C) 1999 Elsevier Science B.V. All rights reserved.