Stability study of piroxicam and cinnoxicam in solid pharmaceuticals

The pseudo-first order rate constant for the hydrolysis of cinnoxicam as a function of temperature was obtained by variable-temperature kinetic experi ments. The method used is on a generalization of non-isothermal analysis, a nd takes advantage of the capabilities of modern data collection and proces sing systems. A spectrophotometric method under non isothermal conditions w as carried out. The results obtained are identical to those obtained under the same conditions by using traditional constant-temperature kinetic runs. This provides the possibility of reducing the amount of time spent and che micals usually used in collecting kinetic data in mechanistic studies in so lution by an order of magnitude. (C) 1999 Elsevier Science B.V. All rights reserved.