Associations of symptoms of sleep apnea with cardiovascular disease, cognitive impairment, and mortality among older Japanese-American men

OBJECTIVES: To examine the association between symptoms of sleep apnea and prevalent cardiovascular disease, cognitive impairment, and subsequent 3-ye ar mortality. DESIGN: A longitudinal study. SETTING: Participants lived in the community on Oahu, Hawaii PARTICIPANTS: A total of 2905 older Japanese-American men participating in the fourth examination of the Honolulu Heart Program cohort study from 1991 -1993, which is the baseline for the Honolulu-Asia Aging Study of dementia. MEASUREMENTS: Self-reported snoring, daytime sleepiness, and breathing paus es; diagnosed cardiovascular disease and dementia; cognitive functioning an d vital status approximately 3 years later. RESULTS: More than 12% of the participants reported that they often or alwa ys snored loudly, and 8% reported being sleepy most of the day. Fewer than 2% reported that they stop breathing when sleeping, and this was found more frequently among habitual snorers (7%, P < .001) and those sleepy during t he day (5%. P < .001). The prevalence of habitual snoring declined in the o lder age groups, was higher among those with greater Body Mass Index scores , and was not associated with the reporting of daytime sleepiness, diagnosi s of heart disease, stroke, dementia, or cognitive impairment. Daytime slee piness was more prevalent at older ages and was associated with a higher pr evalence of heart disease and with cognitive impairment and dementia, chron ic obstructive pulmonary disease, and diabetes. Self-reported apnea was ass ociated only with a history of pneumonia. Three-year mortality was not asso ciated with these symptoms after adjusting for prevalent heart disease and cognitive impairment. CONCLUSION: Symptoms of sleep apnea are reported less frequently in older J apanese-American men. Excessive daytime sleepiness is associated with poor cognition and dementia, but whether it also is an indicator for sleep apnea in this age group remains unclear. Epidemiologic studies of sleep apnea in older adults will require polysomnography to determine accurately the corr elates and consequences of this condition.