This study examines the relationship between sexual behaviors and prevalenc
e of herpes simplex virus-type 2 (HSV-2) among African-American college wom
en. Subjects (n = 138) were recruited randomly from a state university to p
articipate in a study regarding sexual attitudes and behaviors and to have
their blood drawn for type-specific HSV seroprevalence. Sera were analyzed
for 96 college women with a mean age of 21 years. OF the 96 women, 29 (30%)
were HSV-2 seropositive. The results of this study revealed that a history
of sexually transmitted disease was predictive of HSV-2 infection. Number
of lifetime partners, however, was not related to HSV-2 seropositivity Four
(31%) of the 13 women who reported only one lifetime partner were seroposi
tive. These findings indicate that For young African-American college women
, the risk of being infected with HSV-2 is high even with only one lifetime
partner. Behavioral strategies focused on decreasing the number of sexual
partners are not likely to be sufficient in preventing the spread of HSV-2
infection among young African-American women. The development and use of al
ternative approaches to prevent the spread of HSV-2 among young African Ame
ricans should be considered.