Once daily controlled versus immediate release oxybutynin chloride for urge urinary incontinence

Purpose: We compared the efficacy and safety of once daily controlled and i mmediate release oxybutynin for incontinence. Materials and Methods: This multicenter, randomized, double-blind, active c ontrol, parallel study was designed to evaluate urge urinary incontinence e pisodes using a 7-day diary. Results: A total of 97 women and 8 men 34 to 76 years old with urge inconti nence or mixed incontinence with a clinically significant urge component we re enrolled in the study. The number of weekly urge incontinence episodes d ecreased from 27.4 to 4.8 after controlled and from 23.4 to 3.1 after immed iate release oxybutynin (p = 0.56), and total incontinence episodes decreas ed from 29.3 to 6 and from 26.3 to 3.8, respectively (p = 0.6). Weekly urge incontinence episodes from baseline to end of study also decreased to 84% after controlled and 88% after immediate release oxybutynin (p = 0.7). Cont inence was achieved in 41% of the controlled and 40% of the immediate relea se group (p = 0.9). Dry mouth of any severity was reported by 68 and 87% of the controlled and immediate release groups, respectively (p = 0.04), and moderate or severe dry mouth occurred in 25 and 46%, respectively (p = 0.03 ). Conclusions: Participants taking a single daily does of controlled release oxybutynin had similar reductions in urge incontinence and total incontinen ce episodes compared to those taking oxybutynin 1 to 4 times daily. A lower incidence of dry mouth was reported for controlled release oxybutynin.