Clinical evaluation of efficacy of a sustained-release preparation of isosorbide-5-mononitrate in patients with chronic ischemic heart disease

Authors
Pushin, YM Nikolaeva, EP Churina, SK Churin, VD Nedoshivin, AO
Citation
Ym. Pushin et al., Clinical evaluation of efficacy of a sustained-release preparation of isosorbide-5-mononitrate in patients with chronic ischemic heart disease, KARDIOLOGIY, 39(2), 1999, pp. 45-48
Citations number
7
Categorie Soggetti
Cardiovascular & Respiratory Systems
Journal title
KARDIOLOGIYA
ISSN journal
00229040 → ACNP
Volume
39
Issue
2
Year of publication
1999
Pages
45 - 48
Database
ISI
SICI code
0022-9040(1999)39:2<45:CEOEOA>2.0.ZU;2-Q
Abstract
Clinical effect of a sustained-release preparation of isosorbide-5-mononitr ate (Mono-Mack Depot, 50 mg/day) was studied in 27 patients (mean age 53+/- 2 years) with ischemic heart disease and class III-IV effort angina. Distin ct antianginal action of the drug was accompanied by significant increase o f exercise tolerance and according to results of Holter ECG monitoring by d ecrease of number and duration of attacks of ischemia mostly at the account of painless episodes.