Investigations on a flexible prolyl-endopeptidase inhibitor in solution byNMR techniques

Authors
Podanyi, B Bokotey, S Kanai, K Feher, M Hermecz, I
Citation
B. Podanyi et al., Investigations on a flexible prolyl-endopeptidase inhibitor in solution byNMR techniques, MAGN RES CH, 37(5), 1999, pp. 346-352
Citations number
19
Categorie Soggetti
Spectroscopy /Instrumentation/Analytical Sciences
Journal title
MAGNETIC RESONANCE IN CHEMISTRY
ISSN journal
07491581 → ACNP
Volume
37
Issue
5
Year of publication
1999
Pages
346 - 352
Database
ISI
SICI code
0749-1581(199905)37:5<346:IOAFPI>2.0.ZU;2-5
Abstract
4-Phenylbutyrylprolylpyrrolidine, an inhibitor of prolyl-endopeptidase, exi sts in solution as an equilibrium of hans and cis prolyl rotamers. The equi librium ratio and the exchange rate of the rotamers were measured in severa l solvents. The conformational preferences of the flexible molecule were st udied by MMR, based on proton-proton vicinal coupling constants, NOESY cros s peak intensities and aromatic ring current shifts. Copyright (C) 1999 Joh n Wiley & Sons, Ltd.