Structural characterization and dynamic NMR studies of a new peracylated macrocyclic diterpene

Authors
Gunther, G Martinek, T Dombi, G Hohmann, J Vasas, A
Citation
G. Gunther et al., Structural characterization and dynamic NMR studies of a new peracylated macrocyclic diterpene, MAGN RES CH, 37(5), 1999, pp. 365-370
Citations number
20
Categorie Soggetti
Spectroscopy /Instrumentation/Analytical Sciences
Journal title
MAGNETIC RESONANCE IN CHEMISTRY
ISSN journal
07491581 → ACNP
Volume
37
Issue
5
Year of publication
1999
Pages
365 - 370
Database
ISI
SICI code
0749-1581(199905)37:5<365:SCADNS>2.0.ZU;2-4
Abstract
A heptaester of a new diterpene alcohol was isolated from the dichlorometha ne extract of the whole plant of Euphorbia esula L. A detailed NMR and mass spectral analysis revealed that its structure is (E)-(2R*, 3R*, 4S*, 5R*, 7S*, 8R*, 9S*, 13R*, 15R*)-2,3,5,8,9-pentaacetoxy-7-isobutanoyloxy-14-oxoja tropha-6(17),11-diene. Its conformation was studied in three different solu tions. The temperature dependence of the spectral parameters revealed confo rmational changes through internal rotation of the macrocycle part of the m olecule. Copyright (C) 1999 John Wiley & Sons, Ltd.