Therapeutic efficacy of theophylline in chronic lymphocytic leukemia

Authors
Makower, D Malik, U Novik, Y Wiernik, PH
Citation
D. Makower et al., Therapeutic efficacy of theophylline in chronic lymphocytic leukemia, MED ONCOL, 16(1), 1999, pp. 69-71
Citations number
11
Categorie Soggetti
Oncology
Journal title
MEDICAL ONCOLOGY
ISSN journal
13570560 → ACNP
Volume
16
Issue
1
Year of publication
1999
Pages
69 - 71
Database
ISI
SICI code
1357-0560(199904)16:1<69:TEOTIC>2.0.ZU;2-9
Abstract
Theophylline, a methylxanthine commonly used as a treatment for asthma, has been shown to induce apoptosis in chronic lymphocytic leukemia (CLL) cells both in vitro and in vivo. We have treated three advanced CLL patients wit h theophylline, and seen responses in two. The clinical courses of the resp onders are presented, and the literature concerning theophylline as therapy for CLL is reviewed.