In this short review the fundamental differences between pH- and diffusion
controlled drug releases are outlined. In a following step the characterist
ics of single unit- and multiple units-dosage forms are discussed, and the
predominantly used excipients for pH- and diffusion-controlled drug release
are mentioned. Finally rhp influences of such special galenical designs fo
r controlled drug release are explained in the light of some selected examp
les.
The exact knowledge and consideration of these facts are extremely importan
t in the development of optimal drug systems, in the interpretation of resu
lts, and with respect to interdisciplinary cooperation, e.g. between pharma
ceutical technologists and pharmacologists.