Alcohol and postexercise metabolic responses in type 2 diabetes

Citation
Bm. Rasmussen et al., Alcohol and postexercise metabolic responses in type 2 diabetes, METABOLISM, 48(5), 1999, pp. 597-602
Citations number
43
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
METABOLISM-CLINICAL AND EXPERIMENTAL
ISSN journal
00260495 → ACNP
Volume
48
Issue
5
Year of publication
1999
Pages
597 - 602
Database
ISI
SICI code
0026-0495(199905)48:5<597:AAPMRI>2.0.ZU;2-O
Abstract
The objective was to investigate the impact of the combination of exercise and alcohol on the metabolic response in nonfasting and fasting type 2 diab etic subjects. In part 1, 12 untrained middle-aged type 2 diabetic subjects participated on 3 test days. On each day, they ingested a light meal (1,82 4 kJ) containing 48 energy percent (E%) carbohydrate, 38 E% fat, and 14 E% protein. The meal was followed by either (A) rest or (B) 30 minutes of exer cise (40% of maximum O-2 consumption [VO(2)max]) or (C) taken with alcohol (0.4 g/kg body weight) followed by 30 minutes of exercise (40% of VO(2)max) . In part 2, 11 untrained middle-aged type 2 diabetic subjects participated on 4 test days without a meal. The Subjects were either (A) resting, (B) d rinking alcohol (0.4 g/kg body weight), (C) exercising 30 minutes (40% of V O(2)max), or (D) drinking alcohol (0.4 g/kg body weight) and exercising 30 minutes (40% of VO(2)max). On each test day, regular blood samples were dra wn for 4 hours for analysis of glucose, insulin, lactate, triglycerides, no nesterified fatty acid (NEFA), and ethanol. Comparing exercise and rest fol lowing a light meal (part 1, no change (7%) occurred in the plasma glucose response area (642 +/- 119 v 724 +/- 109 mmol.L-1 240 min, NS). However, it was significantly reduced (by 27%) in response to exercise and alcohol (50 9 +/- 98 v 724 +/- 109 mmol.L-1 x 240 min; P = .03). Similar serum insulin response areas were obtained. After exercise and alcohol, plasma lactate in creased compared with the resting state (2.2 +/- 0.2 v 1.6 +/- 0.1 mmol.L-1 , P = .004) and with exercise alone (2.2 +/- 0.2 v 1.8 +/- 0.2 mmol +/- L-1 , P = .04). Serum NEFAs were significantly reduced by exercise and alcohol compared with the resting state (0.50 +/- 0.04 v 0.65 +/- 0.06 mmol.L-1, P = .008) and with exercise alone (0.50 +/- 0.04 v 0.61 +/- 0.05 mmol.L-1, P = .02). Similar serum triglycerides were found. During the fasting state (p art 2), similar plasma glucose response areas were obtained in the four sit uations. The insulin response area to exercise and alcohol increased signif icantly compared with the resting state (3,325 +/- 744 v 882 +/- 295 pmol.L -1 x 240 min, P = .02) and with exercise alone (3,325 +/- 744 v 1,328 +/- 4 22 pmol L-l x 240 min, P = .007). No difference was found compared with alc ohol alone. Plasma lactate was higher after alcohol intake versus the resti ng state (1.9 +/- 0.1 v 1.3 +/- 0.1 mmol.L-1, P = .003), as well as after e xercise and alcohol (1.9 +/- 0.1 v 1.3 +/- 0.1 mmol.L-1, P = .01). After ex ercise and alcohol serum NEFAs were significantly reduced compared with the resting state (0.43 +/- 0.02 v 0.64 +/- 0.02 mmol.L-1, P < .007), alcohol alone (0.43 +/- 0.02 v 0.51 +/- 0.02 mmol.L-1, P < .001), and exercise alon e (0.43 +/- 0.02 v 0.64 +/- 0.02 mmol.L-1, P < .001). Serum triglycerides w ere similar in the four situations. We conclude that moderate exercise with or without moderate alcohol intake does not cause acute hypoglycemia eithe r after a light meal or in the fasting state in untrained overweight type 2 diabetic subjects. Copyright (C) 1999 by W.B. Saunders Company.