The role of intrahepatic gamma delta-T cells for liver injury induced by Salmonella infection in mouse

Liver injury was induced after infection with Salmonella choleraesuis 31N-1 . In T-cell receptor-delta knockout mice, serum alanine transferase level w as significantly decreased in comparison with normal control mice after Sal monella infection. On the contrary, in vivo administration of anti-gamma de lta T-cell receptor monoclonal antibody (UC7-13D5) to stimulate gamma delta -T cells in infected mice significantly increased serum alanine transferase level but decreased bacterial growth compared with infected mice given con trol antibody (UC8; hamster IgG), These data suggest that gamma delta-T cel ls have effector activities not only for protection but also for liver inju ry during Salmonella infection.