Reciprocal adaptive response of human peripheral lymphocytes induced by bleomycine or gamma rays

The adaptive response and reciprocal adaptive response induced in vitro by exposure to low doses of gamma rays (0.05 Gy) or bleomycin (0.05 mu g/ml) i n human peripheral blood lymphocytes were assessed by the frequency of chro mosome aberrations. Gamma rays (1.5 Gy) or bleomycin (1.5 mu g/ml) were use d as the challenge doses. In the experiments, blood samples from 5 healthy donors were investigated. It has been found that low doses of bleomycin and gamma rays induced a reciprocal adaptive response to high doses of gamma r ays or bleomycin. Moreover, the results confirmed that the adaptive respons e did not correlate with the radiosensitivity of the peripheral blood lymph ocytes.