Da. Jett et al., INTRAHIPPOCAMPAL ADMINISTRATION OF LEAD (PB) IMPAIRS PERFORMANCE OF RATS IN THE MORRIS WATER MAZE, Pharmacology, biochemistry and behavior, 57(1-2), 1997, pp. 263-269
We examined spatial learning in the Morris water maze after daily acut
e bilateral micro-injection of 13.9 ng sodium acetate (NaAc) or 37.9 n
g lead acetate (PbAc) in 1 mu l volumes into the dorsal hippocampus of
normal adult rats. After six days of injections and water maze traini
ng, rats injected with NaAc were able to find a hidden platform in 8.3
s, and those injected with PbAc were significantly slower (15.2 s; p
< 0.02). In a second experiment, rats were trained to find a hidden pl
atform before injections began and then tested in order to determine i
f intrahippocampal injections of Pb affected the recall of a previousl
y learned task. The escape latency on the first day after injections b
egan was increased slightly when compared to the last day of training
before injections, however the NaAc and PbAc groups were not significa
ntly different over three days of injections. Both treatment groups pe
rformed as well as they did before injections began by the second day
of injections. These results suggest that the direct injection of Pb i
nto the hippocampus impairs the acquisition, but not the recall of the
spatial learning task in the Morris water maze. (C) 1997 Elsevier Sci
ence Inc.