Rp. Donn et al., Absence of association between interleukin 1 alpha and oligoarticular juvenile chronic arthritis in UK patients, RHEUMATOLOG, 38(2), 1999, pp. 171-175
Objective. To determine whether interleukin 1 alpha (IL-1 alpha) polymorphi
sms are associated with UK oligoarticular juvenile chronic arthritis (JCA).
Patients and controls. A well-characterized population of 164 UK Caucasian
oligo-ICA patients and a control panel of 173 unrelated healthy UK Caucasia
n individuals.
Methods. The IL-1 alpha promoter mutation at -889 was examined using a poly
merase chain reaction-restriction fragment length polymorphism (PCR-RFLP) a
ssay. The cases and controls were also genotyped for an IL-1 alpha intronic
microsatellite repeat.
Results. No association was observed between IL-1 alpha polymorphisms and U
K oligoarticular JCA patients. In particular, no association between IL-1 a
lpha polymorphisms and chronic anterior uveitis was found.
Conclusions. IL-1 alpha is not associated with oligoarticular JCA in UK pat
ients. This differs markedly to findings for IL-1 alpha in Norwegian JCA pa
tients.