Ra. Gadient et Ph. Patterson, Leukemia inhibitory factor, interleukin 6, and other cytokines using the GP130 transducing receptor: Roles in inflammation and injury, STEM CELLS, 17(3), 1999, pp. 127-137
Inflammation refers to a complex set of mechanisms by which tissues respond
to injury and infection. Among the many soluble mediators associated with
this process, cytokines are known to be crucial in regulating a variety of
cellular and molecular events. Leukemia inhibitory factor (LIF), interleuki
n 6 (IL-6), IL-11, and possibly other members of this cytokine family are k
ey mediators in various inflammatory processes such as the acute-phase reac
tion, tissue damage, and infection. These cytokines can act in both pro-inf
lammatory and anti-inflammatory ways, depending on a number of variables. W
e emphasize here recent work utilizing knockout mice, which has highlighted
the roles of LIF and IL-6, particularly in interactions between the immune
and nervous systems.