Purine nucleoside analogues; 9: Benzylation of N-2-acetyl-8-bromoguanine

Authors
Madre, M Panchenko, N Zhuk, R Geenevasen, JA van den Burg, A Koomen, GJ
Citation
M. Madre et al., Purine nucleoside analogues; 9: Benzylation of N-2-acetyl-8-bromoguanine, SYNTHESIS-S, (5), 1999, pp. 775-778
Citations number
20
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
SYNTHESIS-STUTTGART
ISSN journal
00397881 → ACNP
Issue
5
Year of publication
1999
Pages
775 - 778
Database
ISI
SICI code
0039-7881(199905):5<775:PNA9BO>2.0.ZU;2-K
Abstract
A one-step synthesis of regioisomeric N- and O-benzylated 8-bromoguanines 4 , 5, 9, 10 via N-2-acetyl-8-bromoguanine (2) is described. The possibility to prepare 8-oxo- and 8-chloroguanine derivatives 3, 11, 12 from the same c ompound 2 is demonstrated. H-1 and C-13 NMR spectra are used to locate the sites of aralkylation.