An efficient synthesis of new 2-pyronyl-1,5-benzodiazepine derivatives

Authors
Fodili, M Amari, M Kolli, B Robert, A Baudy-Floc'h, M Le Grel, P
Citation
M. Fodili et al., An efficient synthesis of new 2-pyronyl-1,5-benzodiazepine derivatives, SYNTHESIS-S, (5), 1999, pp. 811-814
Citations number
21
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
SYNTHESIS-STUTTGART
ISSN journal
00397881 → ACNP
Issue
5
Year of publication
1999
Pages
811 - 814
Database
ISI
SICI code
0039-7881(199905):5<811:AESON2>2.0.ZU;2-0
Abstract
A series of 3,4-dihydro-2-pyronyl-1,5-benzodiazepines 4 was prepared by the reaction of DHA (dehydroacetic acid), o-PDA (orthophenylenediamine) and ar omatic aldehydes in the presence of a catalytic amount of TFA (trifluoroace tic acid). 2-Pyronyl-1,5-benzodiazepines 6 in turn were synthesised from DH A, o-PDA and acetal [dimethyl formamide-dimethyl acetal (DMF-DMA) or dimeth yl acetamide-dimethyl acetal (DMA-DMA)] under basic catalysis.