Ja. Jansen et al., EVALUATION OF TRICALCIUMPHOSPHATE HYDROXYAPATITE CEMENT FOR TOOTH REPLACEMENT - AN EXPERIMENTAL ANIMAL STUDY, Journal of materials science. Materials in medicine, 6(11), 1995, pp. 653-657
calciumphosphate cement, consisting mainly of tricalciumphosphate (85%
alpha-TCP and 15% beta-TCP), was inserted in 16 surgical defects crea
ted in the tibia of goats. X-ray diffraction (XRD) and energy dispersi
ve spectroscopy (EDS) showed that after 3 months of implantation the a
lpha-TCP was transformed to hydroxyapatite (HA). Histological evaluati
on revealed that the presence of cement stimulated the ingrowth of bon
e compared with unfilled cavities. Active resorption and remodelling o
f cement particles was observed. The cement did not evoke an inflammat
ory reaction. At 6 months after implantation no further changes in the
composition of the cement occurred. All remaining material was surrou
nded by mature bone.