A new lipoid adjuvant: Harmlessness and local reactogenicity

Model experiments on laboratory animals (guinea pigs) were carried out to t est the possible allergy reaction (possibility or sensitization) to the rep eated administration of an experimental lipoid adjuvant (ELA) prepared on t he basis of isopropylpalmitate. No significant differences were observed be tween the animals senzitized-provoked with ELA and the control animals. In older to evaluate the local tissue reactivity (local reactogenicity), also with regard to the process dynamics, to the administration of ELA and to ca rry out comparisons with other types of lipoid adjuvants, as well as alumin ium hydroxide, comparative patho-anatomical and patho-histological examinat ions of tissues were carried out in the location of adjuvant administration . The examinations indicated very low local reactogenicity of the experimen tal lipoid adjuvant prepared in our laboratory.