Although questions may still remain regarding the use of this unique sedati
ve-hypnotic drug with anesthetic properties in highrisk patients, these stu
dies have provided cardiopulmonary and neurologic evidence of the efficacy
and safety of propofol when used as an anesthetic under normal and impaired
conditions in the dog. In nonpremedicated dogs, the quality of induction,
anesthesia, and recovery following propofol is desirable. Muscle relaxation
and the degree of analgesia observed with propofol alone are suitable for
minor diagnostic procedures. The patient is bright and alert within a few m
inutes after propofol anesthesia with excellent psychomotor function. The u
se of potent sedative/analgesics or analgesics enhances the degree of muscl
e relaxation and analgesia desirable for surgical procedures. These studies
have shown propofol to be an anesthetic that can be employed in a wide ran
ge of research and clinical conditions.