We showed that the selection of a cost-effective type of cement and method
of prophylaxis against deep infections for patients undergoing total hip re
placement depended on the number of arthroplasties performed each year at i
ndividual hospitals. When 100 arthroplasties were performed each year, the
use of Palaces cement and systemic antibiotics reduced the total costs to t
he department, i.e., the cost of cement, infection prophylaxis and revision
s. The use of gentamicin-impregnated cement in combination with systemic an
tibiotics will further reduce the risk of revision and is another cost-effe
ctive strategy. The most effective infection prophylaxis would be achieved
with a combination of gentamicin-impregnated cement, systemic antibiotics a
nd surgical enclosure. However, the additional cost of the surgical enclosu
re would not be offset by cost savings due to reduced risk of revisions.