The development of new observational, experimental, and computational
technologies is changing our understanding of the origins of the eleme
nts by thermonuclear burning in stars. Gamma-ray lines from newly made
radioactive nuclei have been identified using instruments onboard low
-Earth orbiting satellites. Grains in meteorites have isotopic anomali
es which suggest that the grains were put together in a stellar explos
ion such as a supernova. Computer simulations allow such anomalies to
be used to probe how these events happen. The simulations are being in
dependently tested by experiments with high-energy density lasers, The
se developments are beginning to provide a quantitative diagnostic of
galactic evolution, and of the epoch of formation of the first stars a
nd galaxies.