The rather slow evolution of so-called "optimal chemotherapy" for ovarian c
ancer is the result of suboptimal randomised clinical trials, not having th
e statistical power to identify truly superior regimens, and of the lack of
systematic comparisons of new agents with relevant control arms. There is
little doubt that we need international collaboration to move the field for
ward in a timely and coherent manner. European and transatlantic collaborat
ion represents the beginning of the process and point to the success that c
an await us if the drive to work together remains strong. A similar organis
ation as for breast cancer (Breast International Group, BIG) needs to be es
tablished for ovarian cancer.