Synthesis and antiproliferative activity of some N-sulphonated-2-substituted benzimidazoles and imidazo[4,5-b]pyridines

Authors
Garuti, L Varoli, L Cermelli, C Baggio, G Lupo, L Malagoli, M Castelli, M
Citation
L. Garuti et al., Synthesis and antiproliferative activity of some N-sulphonated-2-substituted benzimidazoles and imidazo[4,5-b]pyridines, ANTI-CAN DR, 13(8), 1998, pp. 969-980
Citations number
22
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
ANTI-CANCER DRUG DESIGN
ISSN journal
02669536 → ACNP
Volume
13
Issue
8
Year of publication
1998
Pages
969 - 980
Database
ISI
SICI code
0266-9536(199812)13:8<969:SAAAOS>2.0.ZU;2-Y
Abstract
Some N-sulphonated-2-substituted benzimidazoles and imidazo[4,5-b]pyridines were synthesized and tested in vitro for antiviral and antiproliferative a ctivity. None of the compounds had antiviral properties. However, three of them inhibited the proliferation of leukaemia and lymphoma cell lines at mi cromolar concentrations. The maximum potency of antiproliferative activity is correlated with the presence of an ethylenic spacer between the two hete rocycles.