Subacute encephalopathy after combination chemotherapy including moderate-dose methotrexate in a patient with gastric cancer

Authors
Genvresse, I Dietzmann, A Massenkeil, G Spath-Schwalbe, E Possinger, K
Citation
I. Genvresse et al., Subacute encephalopathy after combination chemotherapy including moderate-dose methotrexate in a patient with gastric cancer, ANTI-CANC D, 10(3), 1999, pp. 293-294
Citations number
8
Categorie Soggetti
Pharmacology,"Onconogenesis & Cancer Research
Journal title
ANTI-CANCER DRUGS
ISSN journal
09594973 → ACNP
Volume
10
Issue
3
Year of publication
1999
Pages
293 - 294
Database
ISI
SICI code
0959-4973(199903)10:3<293:SEACCI>2.0.ZU;2-1
Abstract
An episode of subacute encephalopathy after the infusion of a moderate dose of methotrexate (1500 mg/m(2)) (MTX) is reported in a young adult with met astastic gastric cancer. Weakness of the right arm, focal seizures, letharg y and confusion appeared on day 10. High signal intensity in periventricula r white matter was observed on T-2-weighted magnetic resonance imaging. Sym ptoms resolved spontaneously and completely after 48 h. We believe that thi s represents an unusual case of moderate-dose MTX-induced neurotoxicity in a patient with gastric cancer, which has not previously been reported. [(C) 1999 Lippincott Williams & Wilkins.]