I. Genvresse et al., Subacute encephalopathy after combination chemotherapy including moderate-dose methotrexate in a patient with gastric cancer, ANTI-CANC D, 10(3), 1999, pp. 293-294
An episode of subacute encephalopathy after the infusion of a moderate dose
of methotrexate (1500 mg/m(2)) (MTX) is reported in a young adult with met
astastic gastric cancer. Weakness of the right arm, focal seizures, letharg
y and confusion appeared on day 10. High signal intensity in periventricula
r white matter was observed on T-2-weighted magnetic resonance imaging. Sym
ptoms resolved spontaneously and completely after 48 h. We believe that thi
s represents an unusual case of moderate-dose MTX-induced neurotoxicity in
a patient with gastric cancer, which has not previously been reported. [(C)
1999 Lippincott Williams & Wilkins.]