Induction of apoptotic cell death in human hepatocellular carcinoma SK-HEP-1 cells by a polyamine synthesis inhibitor, methylglyoxal bis(cyclopentylamidinohydrazone)

Authors
Hashimoto, Y Hibasami, H Tamaki, S Kamei, A Ikoma, J Kaito, M Imoto, I Watanabe, S Nakashima, K Adachi, Y
Citation
Y. Hashimoto et al., Induction of apoptotic cell death in human hepatocellular carcinoma SK-HEP-1 cells by a polyamine synthesis inhibitor, methylglyoxal bis(cyclopentylamidinohydrazone), ANTI-CANC D, 10(3), 1999, pp. 323-327
Citations number
27
Categorie Soggetti
Pharmacology,"Onconogenesis & Cancer Research
Journal title
ANTI-CANCER DRUGS
ISSN journal
09594973 → ACNP
Volume
10
Issue
3
Year of publication
1999
Pages
323 - 327
Database
ISI
SICI code
0959-4973(199903)10:3<323:IOACDI>2.0.ZU;2-0
Abstract
The antitumor effects of a polyamine biosynthetic pathway inhibitor methylg lyoxal bis(cyclopentylamidinohydrazone) (MGBCP) on the human hepatocellular carcinoma SK-HEP-1 cell line have been investigated. The growth of these c ultured hepatocellular carcinoma cells was inhibited by MGBCP in a dose-dep endent manner. Spermidine and spermine levels were dose-dependently depress ed, and morphological changes due to programmed cell death (apoptosis) were observed in these MGBCP treated hepatocellular carcinoma cells. These resu lts suggest that in addition to reducing the growth rates, MGBCP can induce apoptotic cell death in this human hepatocellular carcinoma cell line, [(C ) 1999 Lippincott Williams & Wilkins.]