Isolation and characterization of a novel human gene (HFB30) which encodesa protein with a RING finger motif

Authors
Ueki, N Seki, N Yano, K Masuho, Y Saito, T Muramatsu, M
Citation
N. Ueki et al., Isolation and characterization of a novel human gene (HFB30) which encodesa protein with a RING finger motif, BBA-GENE ST, 1445(2), 1999, pp. 232-236
Citations number
19
Categorie Soggetti
Molecular Biology & Genetics
Journal title
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
ISSN journal
01674781 → ACNP
Volume
1445
Issue
2
Year of publication
1999
Pages
232 - 236
Database
ISI
SICI code
0167-4781(19990514)1445:2<232:IACOAN>2.0.ZU;2-J
Abstract
A human cDNA, HFB30, encoding a novel protein that contains a RING finger ( C3HC4-type zinc finger) motif was isolated. This cDNA clone consists of 305 6 nucleotides and encodes an open reading frame of a 474 amino acid protein . From RT-PCR analysis, the messenger RNA was ubiquitously expressed in var ious human tissues. The gene was located to the chromosome 5q23.3-q31.1 reg ion by PCR-based analyses with both a human/rodent monochromosomal hybrid c ell panel and a radiation hybrid mapping panel. Furthermore, the gene consi sts of nine exons that span about 20 kb of genome DNA. (C) 1999 Elsevier Sc ience B.V. All rights reserved.