T. Asano et al., CHANGES IN VOLUME AND COMPRESSION ENERGY UPON COMPRESSION OF CALCIUM SILICATE TABLETS, Drug development and industrial pharmacy, 23(7), 1997, pp. 679-685
The compression mechanism of calcium silicate (Florite(R) RE, FLR) was
evaluated by determining the physicochemical properties such as compr
ession energy, volume reduction percentage during the compression proc
ess, and elastic recovery of FLR tablets. The results obtained were co
mpared with those of microcrystalline cellulose (MCC), anhydrous dibas
ic calcium phosphate (ADCP), cornstarch (CS), and lactose (ZAG). FLR i
s found to have higher plasticity in the compression process and lower
elastic recovery in a wide range of tablet hardnesses compared with t
he other 4 excipients. The results also indicate that a large part of
compression energy was consumed for plastic deformation and fragmentat
ion of particles, These characteristics are attributable to FLR's poro
us structure and are responsible for FLR tablets' high hardness, an im
portant property in tablet formulation. As a consequence, it was sugge
sted that FLR would be a useful excipient for the formation of tablets
in the pharmaceutical industry.