CHANGES IN VOLUME AND COMPRESSION ENERGY UPON COMPRESSION OF CALCIUM SILICATE TABLETS

Citation
T. Asano et al., CHANGES IN VOLUME AND COMPRESSION ENERGY UPON COMPRESSION OF CALCIUM SILICATE TABLETS, Drug development and industrial pharmacy, 23(7), 1997, pp. 679-685
Citations number
12
Categorie Soggetti
Chemistry Medicinal","Pharmacology & Pharmacy
ISSN journal
03639045
Volume
23
Issue
7
Year of publication
1997
Pages
679 - 685
Database
ISI
SICI code
0363-9045(1997)23:7<679:CIVACE>2.0.ZU;2-2
Abstract
The compression mechanism of calcium silicate (Florite(R) RE, FLR) was evaluated by determining the physicochemical properties such as compr ession energy, volume reduction percentage during the compression proc ess, and elastic recovery of FLR tablets. The results obtained were co mpared with those of microcrystalline cellulose (MCC), anhydrous dibas ic calcium phosphate (ADCP), cornstarch (CS), and lactose (ZAG). FLR i s found to have higher plasticity in the compression process and lower elastic recovery in a wide range of tablet hardnesses compared with t he other 4 excipients. The results also indicate that a large part of compression energy was consumed for plastic deformation and fragmentat ion of particles, These characteristics are attributable to FLR's poro us structure and are responsible for FLR tablets' high hardness, an im portant property in tablet formulation. As a consequence, it was sugge sted that FLR would be a useful excipient for the formation of tablets in the pharmaceutical industry.