S1319: A novel beta(2)-adrenoceptor agonist from a marine sponge Dysidea sp.

Authors
Suzuki, H Shindo, K Ueno, A Miura, T Takei, M Sakakibara, M Fukamachi, H Tanaka, J Higa, T
Citation
H. Suzuki et al., S1319: A novel beta(2)-adrenoceptor agonist from a marine sponge Dysidea sp., BIOORG MED, 9(10), 1999, pp. 1361-1364
Citations number
8
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
10
Year of publication
1999
Pages
1361 - 1364
Database
ISI
SICI code
0960-894X(19990517)9:10<1361:SANBAF>2.0.ZU;2-3
Abstract
In the course of screening of potential leads for beta(2)-receptor agonists , we found a novel beta(2)- adrenoceptor selective agonist, S1319, from a m arine sponge Dysidea sp. The active compound was isolated and structurally characterized as 4-hydroxy-7-[1-(1-hydroxy-2-methylamino)ethyl]-1, 3-benzot hiazole-2(3H)-one, a new member of the beta(2)-adrenoceptor agonist. This i s the first example of a sponge-derived beta(2)-adrenoceptor agonist. (C) 1 999 Elsevier Science Ltd. All rights reserved.