Uncarinic acids: Phospholipase C gamma 1 inhibitors from hooks of Uncaria rhynchophylla

Authors
Lee, JS Yang, MY Yeo, H Kim, J Lee, HS Ahn, JS
Citation
Js. Lee et al., Uncarinic acids: Phospholipase C gamma 1 inhibitors from hooks of Uncaria rhynchophylla, BIOORG MED, 9(10), 1999, pp. 1429-1432
Citations number
9
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
10
Year of publication
1999
Pages
1429 - 1432
Database
ISI
SICI code
0960-894X(19990517)9:10<1429:UAPCG1>2.0.ZU;2-Z
Abstract
Bioactivity-guided fractionation of the CHCl3 extract from hooks of Uncaria rhynchophylla led to the isolation of two triterpene esters, namely uncari nic acids A (1) and B (2). Their structures were established by spectroscop ic and chemical methods. These compounds inhibited phospholipase C gamma l with IC50 values of 35.66 and 44.55 mu M, respectively. (C) 1999 Elsevier S cience Ltd. All rights reserved.