Syntheses of (+/-)-shinflavanone and its structural analogues as potent inhibitors of bone resorption pits formation

Authors
Suh, H Lee, S Kim, N Han, J Kim, J
Citation
H. Suh et al., Syntheses of (+/-)-shinflavanone and its structural analogues as potent inhibitors of bone resorption pits formation, BIOORG MED, 9(10), 1999, pp. 1433-1436
Citations number
11
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
10
Year of publication
1999
Pages
1433 - 1436
Database
ISI
SICI code
0960-894X(19990517)9:10<1433:SO(AIS>2.0.ZU;2-L
Abstract
The first total syntheses of (+/-)-shinflavanone and its structural analogu es were achieved. (+/-)Shinflavanone, appears to be a strong inhibitor of b one resorption pits formation by osteoclast-like cell induced by 1 alpha, 2 5-dihydroxy vitamine D-3 (IC50 = 0.70 mu g/mL) (C) 1999 Elsevier Science Lt d. All rights reserved.