Adenosine-5 '-carboxylic acid peptidyl derivatives as inhibitors of protein kinases

A new class of protein kinase bisubstrate-analog inhibitors was designed on the basis of adenosine-5'-carboxylic acid derivatives, where a short pepti de was attached to the 5'-carbon atom of the adenosine sugar moiety via a l inker chain. The potency and selectivity of these inhibitors were adjusted by relevant combination of these structural fragments, resembling the struc ture of the bisubstrate complex of the peptide phosphorylation reaction. (C ) 1999 Elsevier Science Ltd. All rights reserved.