A new class of protein kinase bisubstrate-analog inhibitors was designed on
the basis of adenosine-5'-carboxylic acid derivatives, where a short pepti
de was attached to the 5'-carbon atom of the adenosine sugar moiety via a l
inker chain. The potency and selectivity of these inhibitors were adjusted
by relevant combination of these structural fragments, resembling the struc
ture of the bisubstrate complex of the peptide phosphorylation reaction. (C
) 1999 Elsevier Science Ltd. All rights reserved.