Adenosine-5 '-carboxylic acid peptidyl derivatives as inhibitors of protein kinases

Citation
M. Loog et al., Adenosine-5 '-carboxylic acid peptidyl derivatives as inhibitors of protein kinases, BIOORG MED, 9(10), 1999, pp. 1447-1452
Citations number
23
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
10
Year of publication
1999
Pages
1447 - 1452
Database
ISI
SICI code
0960-894X(19990517)9:10<1447:A'APDA>2.0.ZU;2-X
Abstract
A new class of protein kinase bisubstrate-analog inhibitors was designed on the basis of adenosine-5'-carboxylic acid derivatives, where a short pepti de was attached to the 5'-carbon atom of the adenosine sugar moiety via a l inker chain. The potency and selectivity of these inhibitors were adjusted by relevant combination of these structural fragments, resembling the struc ture of the bisubstrate complex of the peptide phosphorylation reaction. (C ) 1999 Elsevier Science Ltd. All rights reserved.